Course Content
UPSC Notes Samples
Full Syllabus Covered | 100% as per Official UPSC Syllabus
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1. Art & Culture Sample
Covered under topic 1. Indian culture will cover the salient aspects of Art Forms, Literature and Architecture from ancient to modern times.
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1. Indian culture will cover the salient aspects of Art Forms, Literature and Architecture from ancient to modern times. (copy)
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2. Modern Indian history from about the middle of the eighteenth century until the present- significant events, personalities, issues. (copy)
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5. History of the world will include events from the 18th century such as Industrial revolution, World wars, Redrawal of national boundaries, Colonization, Decolonization, Political philosophies like Communism, Capitalism, Socialism etc.- their forms and effect on the society.
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7. Role of women and women’s organizations, Population and associated issues, Poverty and developmental issues, Urbanization, their problems and their remedies.
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10.2. Introduction to Maps
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GS2
All topics that need updates are given below.
2. Functions and responsibilities of the Union and the States, issues and challenges pertaining to the federal structure, devolution of powers and finances up to local levels and challenges therein.
All topics that need updates are given below.
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5. Parliament and State Legislatures – structure, functioning, conduct of business, powers & privileges and issues arising out of these.
All topics that need updates are given below.
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6. Structure, organization and functioning of the Executive and the Judiciary; Ministries and Departments of the Government; pressure groups and formal/informal associations and their role in the Polity.
All topics that need updates are given below.
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12. Welfare schemes for Vulnerable Sections of the Population by the Centre and States and the Performance of these schemes; Mechanisms, Laws, Institutions and Bodies constituted for the Protection and Betterment of these Vulnerable Sections.
All topics that need updates are given below.
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GS3
All topics that need updates are given below.
11. Science and Technology- developments and their applications and effects in everyday life.
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GS3: BIODIVERSITY AND ENVIRONMENT
All topics that need updates are given below.
1. Environment
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GS4
All topics that need updates are given below.
GS3: SCIENCE AND TECHNOLOGY
All topics given below
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1. Motion & Measurements
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9. Metals & Non-Metals
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10. Energy
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12. Plant Organisms
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14. Life Processes
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18. Biotechnology
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19. Information Technology
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20. Space Technology
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National & International Current Affairs (CA) 2025
Current affairs of all months are given below
delete UPSC Sample Notes [English]

xiii. RNA and Central Dogma

RNA

  • While DNA encodes instructions to build life, RNA molecule read and act on the information.
  • It simply copies the instruction and carry it to other parts of the cells to make proteins.
  • Recent understanding has shown RNA has much bigger role than acting as a messenger. (more on this later)
  • In terms of molecule, the only difference in RNA is an extra OH group which makes is unstable.
  • Thus, the major difference between DNA and RNA is that while DNA is more permanent RNA is not permanent.

Central Dogma

  • The central dogma of molecular biology explains the how genetic information flows from DNA to proteins.
  • This simply describes how the code of life is brought to life.
  • This happens in two-stages called transcription and translation.
  • In short DNA is transcribed into RNA which is then read by ribosome to make Proteins which are the building blocks of life.
  • Note that advancements in biotechnology coincide with the increased understanding of the central dogma.

Central dogma (cookbook analogy)

  • Consider DNA to be a cookbook of recipes for making proteins. Transcription is the process of photocopying the recipe. This is done by mRNA, short for messenger RNA, inside the nucleus.
  • Once copied the recipe mRNA goes outside the nucleus to the chef, called ribosome.
  • There is also a translator, tRNA who translates mRNA recipe to rRNA of the ribosome which then makes amino acids, the building blocks of proteins.
  • A block of 3 letters in the mRNA correspond to ‘cooking’ of 1 amino acid.
  • Each 3-letter base in mRNA that is read by tRNA that correspond to one amino acid is called ‘codon’.
  • Many amino acids come together to form the primary structure of protein.
  • The primary structure is twisted and folded to make a 3-d structure of protein.

Gene

  • The coding part of protein are called as genes.
  • According to recent understanding there are about 20500 genes in human genome.
  • Genes vary in complexity. They range in size from few hundred bases to more than 2 million.
  • 98% of the genome is non-coding regions.