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What is a virus?
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Viruses are not plants, animals, or bacteria. They are generally placed in their kingdom.
- In the strictest sense, they should not even be considered organisms – because they are not free-living. They cannot reproduce and carry on metabolic processes without a host cell.
- It is an acellular organism that is 10 to 100 times smaller than bacteria, about 20-300 nm in size.
- They can infect a variety of living organisms, including bacteria, plants, and animals.
- The infective, extracellular (outside the cell) form of a virus is called the virion.
- It is a small collection of genetic code (either DNA or RNA) surrounded by a protein coat.
- They lack metabolic machinery of their own to generate energy or synthesize proteins. They can reproduce only within a living cell – hence they are obligate intracellular parasites. They take over the functions of the host cell hence causing infection.
- They are inactive outside the host (crystallized form) and active inside. This puts them in the unique criteria of living as well as the non-living entity or ‘not truly living’.
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History
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- Louis Pasteur (1822-1895) speculated a pathogen too small to be detected by microscopes. This was because he was unable to find the cause of rabies.
- The earliest indications of the biological nature of viruses came from studies in 1892 by the Russian scientist Dmitry I. Ivanovsky.
- Dutch scientist Martinus W. Beijerinck surmised that the virus was a new kind of infectious agent.
- Both Ivanovsky and Beijerinck found that a disease of tobacco plants could be transmitted by an agent, later called the tobacco mosaic virus.
- In the early 20th century, the English bacteriologist Frederick Twort discovered a group of viruses that infect bacteria, now called bacteriophages.
- The first images of viruses were obtained upon the invention of electron microscopy in 1931 by the German engineers Ernst Ruska and Max Knoll.
- The second half of the 20th century saw the discovery and documentation of many viruses.
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Structure
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- They may be either rod-shaped or spherical.
- They consist of one or more molecules of either DNA or RNA enclosed in a coat of protein. This coat protects the genetic material when the virus is outside of the host cell.
- Now, let’s try to understand it from the inside to the outside.
- Nucleic Acid: Starting from the inside, you will see a nucleic acid, which can be either RNA or DNA. The nucleic acid can be either single-stranded or double-stranded.
- Protein Coat: Surrounding the nucleic acid almost all viruses will have a protein coat. This will either be in the form of a capsid or little small units.
- Envelope: Some viruses will also have an envelope that they obtain as they emerge from the cell.
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How are they classified?
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Researchers estimate that viruses outnumber bacteria by 10 to 1.
They are classified according to various criteria such as morphology, nucleic acid type, their host, etc.
Classification based on nucleic acid type:
- DNA viruses – can be single-stranded or double-stranded
- RNA viruses – can be single-stranded or double-stranded
Classification based on host type:
- Hosted by humans
- Hosted by bacteria (bacteriophage)
- Hosted by animals
- Hosted by plants
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Can antibiotics be used against viruses?
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- As they don’t have the same components as bacteria, they cannot be killed by antibiotics.
- Antiviral medications or vaccines can eliminate or reduce the severity of several viral diseases.
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